nfections Immune Disorders, and Compensatory Mechanisms

APA format MSN degree 2 references fromWalden University Library must be peer review 1 and half pages not including reference.  Due 3/16/2018 at 10pm EST


nfections Immune Disorders, and Compensatory Mechanisms

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For the purpose of this assignment, I have chosen to write about Systemic Lupus Erythematosus and Psoriasis. Systemic Lupus Erythematosus (SLE) is an autoimmune disease that causes inflammation in different tissues of the body. Autoimmune diseases affect approximately 8% of the population, affecting more women than men (Arcangelo, Peterson, Wilbur, & Reinhold, 2017). Autoimmune diseases occur when the body’s immune system attacks its own tissues. The diagnosis of SLE is based on a combination of clinical findings and laboratory evidence. Familiarity (Medscape, 2017). Systemic Lupus Erythematosus has the potential to be life-threatening and the symptoms of SLE include fatigue, pain or swelling in joints, skin rashes, and fevers (CDC, 2018).

The treatment for Systemic Lupus Erythematosus consists mainly of drugs that prevent inflammation including hydroxychloroquine and corticosteroids. approved by the FDA for the (CDC,2018). Additionally, systemic lupus erythematous (SLE) often require treatment with intense immunosuppression. For example, high dose corticosteroids with the alkylating agent cyclophosphamide, antimetabolites such as methotrexate, azathioprine, or biological therapy such as rituximab or belimumab (Berman, & Belmont, 2017). It is vital to educate the patients of the potential side effects of these drugs including the risk for infection, inclusive of bacteria, viruses, and fungi (Berman, & Belmont, 2017).


Psoriasis is a chronic autoimmune skin disease that is characterized by rapid growth of skin cells. Some of the symptoms of Psoriasis include patches of thick red skin and silvery scales. The areas where these patches are more commonly found are the elbows, knees, scalp, lower back, face, palms, and soles of feet (CDC, 2016).

Treatments for psoriasis range from creams and ointments for affected areas and ultraviolet light therapy to drugs, for example, methotrexate. Topical calcipotriol and betamethasone dipropionate cutaneous foam consider the safest and effective topical treatments for mild-to-moderate psoriasis, however, adherence to the treatment is crucial for its effectiveness. Appropriate patient education is important for a patient to follow the treatment recommendation (Svendsen, Andersen, Andersen, & Andersen, 2018).


Arcangelo, V. P., Peterson, A. M., Wilbur, V. & Reinhold, J. A.  (Eds.). (2017).

Pharmacotherapeutics for advanced practice: A practical approach (4th ed.). Ambler, PA:

Lippincott Williams & Wilkins.

Berman, N., & Belmont, H. M. (2017). Disseminated cytomegalovirus infection complicating

active treatment of systemic lupus erythematosus: an emerging problem. Lupus, 26(4),

431-434. doi:10.1177/0961203316671817

Laureate Education, Inc. (Executive Producer). (2012b). Antimicrobials. Baltimore, MD: Author.

Lupus. (2018, January 08). Retrieved March 15, 2018, from

Psoriasis. (2016, February 09). Retrieved March 14, 2018, from

Svendsen, M. T., Andersen, F., Andersen, K. H., & Andersen, K. E. (2018). Can an app

supporting psoriasis patients improve adherence to topical treatment? A single-blind

randomized controlled trial. BMC Dermatology, 18(1), 2. doi:10.1186/s12895-018-0071-


Systemic Lupus Erythematosus (SLE). (2017, December 06). Retrieved March 14, 2018, from

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